LymphedemaV1, Main, Exploration, bibRecord, 003C71

Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer

Identifieur interne : 003C71 ( Main/Exploration ); précédent : 003C70; suivant : 003C72

Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer

Auteurs : Ian S. Dayes [Canada] ; Tim J. Whelan [Canada] ; Jim A. Julian [Canada] ; Sameer Parpia [Canada] ; Kathleen I. Pritchard [Canada] ; David Paul D'Souza [Royaume-Uni, Canada] ; Lyn Kligman [Royaume-Uni] ; Donna Reise [Canada] ; Linda Leblanc [États-Unis] ; Margaret L. Mcneely [Canada] ; Lee Manchul [Canada] ; Jennifer Wiernikowski [Canada] ; Mark N. Levine [Canada]

Source :

Journal of clinical oncology [ 0732-183X ] ; 2013.

RBID : Pascal:13-0357345

Descripteurs français

Pascal (Inist)
- Lymphoedème, Essai clinique, Randomisation, Cancer du sein, Lymphatique, Système lymphatique, Traitement, Homme, Femelle, Adulte, Femme, Cancérologie.
Wicri :
- topic : Homme, Adulte, Femme.

English descriptors

KwdEn :
- Adult, Breast cancer, Cancerology, Clinical trial, Female, Human, Lymphatic, Lymphatic system, Lymphedema, Randomization, Treatment, Woman.

Abstract

Purpose Because of its morbidity and chronicity, arm lymphedema remains a concerning complication of breast cancer treatment. Although massage-based decongestive therapy is often recommended, randomized trials have not consistently demonstrated benefit over more conservative measures. Patients and Methods Women previously treated for breast cancer with lymphedema were enrolled from six institutions. Volumes were calculated from circumference measurements. Patients with a minimum of 10% volume difference between their arms were randomly assigned to either compression garments (control) or daily manual lymphatic drainage and bandaging followed by compression garments (experimental). The primary outcome was percent reduction in excess arm volume from baseline to 6 weeks. Results A total of 103 women were randomly assigned, and 95 were evaluable. Mean reduction of excess arm volume was 29.0% in the experimental group and 22.6% in the control group (difference, 6.4%; 95% CI, -6.8% to 20.5%; P = .34). Absolute volume loss was 250 mL and 143 mL in the experimental and control groups, respectively (difference, 107 mL; 95% CI, 13 to 203 mL; P = .03). There was no difference between groups in the proportion of patients losing 50% or greater excess arm volume. Quality of life (Short Form-36 Health Survey) and arm function were not different between groups. Conclusion This trial was unable to demonstrate a significant improvement in lymphedema with decongestive therapy compared with a more conservative approach. The failure to detect a difference may have been a result of the relatively small size of our trial.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000018
to stream PascalFrancis, to step Curation: 000937
to stream PascalFrancis, to step Checkpoint: 000027
to stream Main, to step Merge: 003C80
to stream Main, to step Curation: 003C71

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer</title>
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<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Reise, Donna" sort="Reise, Donna" uniqKey="Reise D" first="Donna" last="Reise">Donna Reise</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Talspar Nursing Services</s1>
<s3>CAN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Talspar Nursing Services</wicri:noRegion>
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<author><name sortKey="Leblanc, Linda" sort="Leblanc, Linda" uniqKey="Leblanc L" first="Linda" last="Leblanc">Linda Leblanc</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Dr Leon Richard Oncology Centre</s1>
<s2>Moncton, New Brunswick</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Dr Leon Richard Oncology Centre</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L." last="Mcneely">Margaret L. Mcneely</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>University of Alberta</s1>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>University of Alberta</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Cross Cancer Institute</s1>
<s2>Edmonton, Alberta</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Cross Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manchul, Lee" sort="Manchul, Lee" uniqKey="Manchul L" first="Lee" last="Manchul">Lee Manchul</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>University Health Network</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>University Health Network</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiernikowski, Jennifer" sort="Wiernikowski, Jennifer" uniqKey="Wiernikowski J" first="Jennifer" last="Wiernikowski">Jennifer Wiernikowski</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Hamilton Health Sciences</s1>
<s2>Hamilton</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Hamilton Health Sciences</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Levine, Mark N" sort="Levine, Mark N" uniqKey="Levine M" first="Mark N." last="Levine">Mark N. Levine</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>McMaster University</s1>
<s3>CAN</s3>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université McMaster</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ontario Clinical Oncology Group</s1>
<s3>CAN</s3>
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<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Ontario Clinical Oncology Group</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Juravinski Cancer Centre</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Juravinski Cancer Centre</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Breast cancer</term>
<term>Cancerology</term>
<term>Clinical trial</term>
<term>Female</term>
<term>Human</term>
<term>Lymphatic</term>
<term>Lymphatic system</term>
<term>Lymphedema</term>
<term>Randomization</term>
<term>Treatment</term>
<term>Woman</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Lymphoedème</term>
<term>Essai clinique</term>
<term>Randomisation</term>
<term>Cancer du sein</term>
<term>Lymphatique</term>
<term>Système lymphatique</term>
<term>Traitement</term>
<term>Homme</term>
<term>Femelle</term>
<term>Adulte</term>
<term>Femme</term>
<term>Cancérologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Adulte</term>
<term>Femme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose Because of its morbidity and chronicity, arm lymphedema remains a concerning complication of breast cancer treatment. Although massage-based decongestive therapy is often recommended, randomized trials have not consistently demonstrated benefit over more conservative measures. Patients and Methods Women previously treated for breast cancer with lymphedema were enrolled from six institutions. Volumes were calculated from circumference measurements. Patients with a minimum of 10% volume difference between their arms were randomly assigned to either compression garments (control) or daily manual lymphatic drainage and bandaging followed by compression garments (experimental). The primary outcome was percent reduction in excess arm volume from baseline to 6 weeks. Results A total of 103 women were randomly assigned, and 95 were evaluable. Mean reduction of excess arm volume was 29.0% in the experimental group and 22.6% in the control group (difference, 6.4%; 95% CI, -6.8% to 20.5%; P = .34). Absolute volume loss was 250 mL and 143 mL in the experimental and control groups, respectively (difference, 107 mL; 95% CI, 13 to 203 mL; P = .03). There was no difference between groups in the proportion of patients losing 50% or greater excess arm volume. Quality of life (Short Form-36 Health Survey) and arm function were not different between groups. Conclusion This trial was unable to demonstrate a significant improvement in lymphedema with decongestive therapy compared with a more conservative approach. The failure to detect a difference may have been a result of the relatively small size of our trial.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Ontario</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
<li>Londres</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université McMaster</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Dayes, Ian S" sort="Dayes, Ian S" uniqKey="Dayes I" first="Ian S." last="Dayes">Ian S. Dayes</name>
</region>
<name sortKey="D Souza, David Paul" sort="D Souza, David Paul" uniqKey="D Souza D" first="David Paul" last="D'Souza">David Paul D'Souza</name>
<name sortKey="Dayes, Ian S" sort="Dayes, Ian S" uniqKey="Dayes I" first="Ian S." last="Dayes">Ian S. Dayes</name>
<name sortKey="Julian, Jim A" sort="Julian, Jim A" uniqKey="Julian J" first="Jim A." last="Julian">Jim A. Julian</name>
<name sortKey="Julian, Jim A" sort="Julian, Jim A" uniqKey="Julian J" first="Jim A." last="Julian">Jim A. Julian</name>
<name sortKey="Levine, Mark N" sort="Levine, Mark N" uniqKey="Levine M" first="Mark N." last="Levine">Mark N. Levine</name>
<name sortKey="Levine, Mark N" sort="Levine, Mark N" uniqKey="Levine M" first="Mark N." last="Levine">Mark N. Levine</name>
<name sortKey="Levine, Mark N" sort="Levine, Mark N" uniqKey="Levine M" first="Mark N." last="Levine">Mark N. Levine</name>
<name sortKey="Manchul, Lee" sort="Manchul, Lee" uniqKey="Manchul L" first="Lee" last="Manchul">Lee Manchul</name>
<name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L." last="Mcneely">Margaret L. Mcneely</name>
<name sortKey="Mcneely, Margaret L" sort="Mcneely, Margaret L" uniqKey="Mcneely M" first="Margaret L." last="Mcneely">Margaret L. Mcneely</name>
<name sortKey="Parpia, Sameer" sort="Parpia, Sameer" uniqKey="Parpia S" first="Sameer" last="Parpia">Sameer Parpia</name>
<name sortKey="Parpia, Sameer" sort="Parpia, Sameer" uniqKey="Parpia S" first="Sameer" last="Parpia">Sameer Parpia</name>
<name sortKey="Pritchard, Kathleen I" sort="Pritchard, Kathleen I" uniqKey="Pritchard K" first="Kathleen I." last="Pritchard">Kathleen I. Pritchard</name>
<name sortKey="Pritchard, Kathleen I" sort="Pritchard, Kathleen I" uniqKey="Pritchard K" first="Kathleen I." last="Pritchard">Kathleen I. Pritchard</name>
<name sortKey="Pritchard, Kathleen I" sort="Pritchard, Kathleen I" uniqKey="Pritchard K" first="Kathleen I." last="Pritchard">Kathleen I. Pritchard</name>
<name sortKey="Reise, Donna" sort="Reise, Donna" uniqKey="Reise D" first="Donna" last="Reise">Donna Reise</name>
<name sortKey="Whelan, Tim J" sort="Whelan, Tim J" uniqKey="Whelan T" first="Tim J." last="Whelan">Tim J. Whelan</name>
<name sortKey="Whelan, Tim J" sort="Whelan, Tim J" uniqKey="Whelan T" first="Tim J." last="Whelan">Tim J. Whelan</name>
<name sortKey="Whelan, Tim J" sort="Whelan, Tim J" uniqKey="Whelan T" first="Tim J." last="Whelan">Tim J. Whelan</name>
<name sortKey="Wiernikowski, Jennifer" sort="Wiernikowski, Jennifer" uniqKey="Wiernikowski J" first="Jennifer" last="Wiernikowski">Jennifer Wiernikowski</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="D Souza, David Paul" sort="D Souza, David Paul" uniqKey="D Souza D" first="David Paul" last="D'Souza">David Paul D'Souza</name>
</region>
<name sortKey="Kligman, Lyn" sort="Kligman, Lyn" uniqKey="Kligman L" first="Lyn" last="Kligman">Lyn Kligman</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Leblanc, Linda" sort="Leblanc, Linda" uniqKey="Leblanc L" first="Linda" last="Leblanc">Linda Leblanc</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer

Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer

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